. Fieber, thermotaxis, und kalorimetrie von Malaria, Fieber. In 24 bis 48 Stunden, von 1070, andlasts über drei Tage. Am anderen Ende des halben Zoll, bypuncture eine Temperatur von 1091/2 0 in drei Stunden, andlasts erreicht ist, aber eine kurze Zeit, die Rückkehr zu normalen in vier oder fünf Stunden. Zwischen diesen beiden Punkten sind zwei weitere Zentren, die whenpunctured mit Temperaturen von Io 5°-io5.5, der schnell erreicht und etwa drei Tage fortgesetzt werden. Temper - reif ist, wie sensibel diese thermotaxic basalcenters wie arteriellen Spannungen zu Irritationen der entfernten Teile der Läsion, DIE DEN R

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. Fever, thermotaxis, and calorimetry of malarial fever. , in twenty-four to forty-eight hours, of 1070, andlasts about three days. At the other end of the half inch, bypuncture a temperature of 1091/2 0 is attained in three hours, andlasts but a short time, returning to normal in four or five hours.Between these two points are two other centres which whenpunctured are associated with temperatures of io5°-io5.5, rapidly reached and continued about three days. Temper-ature is as sensitive to lesion about these thermotaxic basalcentres as arterial tension to irritations of distant parts ; THE THE RMO-POL YPNCEIC CENTRE. 2 I but these changes in arterial pressure do not prove that nochief vaso-motor centre exists. I should like to state herethat whilst a rise of temperature is often attained by insultsto these centres at the base of the brain, it by no meansfollows that it always does ; for I have often seen the re-verse happen with the same sized probe, under the sameexternal circumstances, and about in the same situation in JZxp. 229. Temp.105. Hours/ Fig. Q. the brain. I regard this fact an important proof that thesecentres preside over the relation of heat production to heatdissipation ; and if this relation is disordered so that thetemperature falls, it shows that the thermotaxic centres arenot necessarily connected directly with heat production. My calorimetric experiments upon the thermotaxic cen-tres, when continued for several hours, showed sometimesincreased production, at other times a decreased productionof heat. 2 2 ISAAC OTJ. Usually there was a temporary elevation of heat pro-duction shortly after the injury. At the late Congress, Dr.Ferrier alluded to these thermotaxic centres as probablyconcerned in trophic work, and inferred that there must beseveral to preside over the tissues of the body. I have fre-quently seen great wasting of the body in large and well-developed rabbits after injury of the caudate nucleus, al-though their appetite was excellent. A

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